Sipho Ncube started participating in humanitarian work at the age of 18 through volunteering with organizations such as World Vision International as well as Generation Earth. She has been working on SDGs 3 and 4.
In 2020 Sipho was listed as one of the top 200 young South Africans under 35 years of age in the Health Category by Mail and Guardian. She is currently working with an organization called Sethule Orphans Trust on a project titled “A Birth of Hope” which proactively works to address the issue of birth registration in rural areas by assisting to provide unregistered orphans and vulnerable children with birth certificates so that they can enroll in schools and get access to healthcare and no longer face challenges of not existing in the system. To date this project has helped children in the Matabeleland South region in Bulawayo Zimbabwe to successfully complete school examinations and move on to secondary and higher education.
Sipho an active member of the United Nations Association of USA as a youth advocate and mentor. She has participated in the Utah Health Scholars program and Days for Girls.Through health education, she has assisted to make reusable sanitary pads and helped to shatter stigmas and limitations for girls living in rural communities, mainly ensuring that they get a quality education by not missing school because of their menstrual cycle. In 2016 she became a member of the International Federation of Medical Students Association. She has received numerous awards including for leadership.